From Lab to Market

Digital scanning technologies, which make it possible to measure teeth and the interior of the mouth with high precision using optical cameras, are becoming increasingly common in dental practices. In addition to providing measurements for dental prostheses, these scan data open up a wide range of diagnostic possibilities. The spin-off Dentexion GmbH is developing a software platform that enables dentists to analyze 3D data from patients mouths and evaluate changes over time. The technology, developed at the Computer-Assisted Restorative Dentistry Department, uses AI to analyze 3D scans of components such as teeth, gums and bone in order to detect and document pathological changes at an early stage, which is particularly helpful in cases of tooth tissue loss or inflammation.
 

Food, tap water or even air particles can be contaminated with lead, which poses serious health risks. Even small amounts of the heavy metal can lead to kidney damage, anemia, high blood pressure, cardiovascular failure and cognitive and neurological impairments.

There are currently only two drugs available to treat severe lead poisoning, and over 90 percent of diagnosed cases are left untreated. Chemist Michal Shoshan aims to change this situation with her spin-off metaLead Therapeutics AG. She and her team at the Department of Chemistry have developed novel short peptides that do not have the disadvantages of conventional therapies. They have synthesized around 50 peptides, eight of which show promising properties. The leading substance so far, which has been tested in animal models, has been found to significantly reduce lead levels in the blood, brain and liver without impairing essential metal concentrations.

The spin-off ATLyphe AG is developing antibodies to stimulate immune cells that could be used to treat blood stem cell diseases in the future. The current main project focuses on an antibody that activates T-cells to fight acute myeloid leukemia. Due to the structural similarities between diseased leukemia cells and healthy blood stem cells, this biospecific antibody could also be used in the future in advance of transplants of foreign or genetically corrected hematopoietic stem cells. This would be a promising treatment option not only for patients with acute myeloid leukemia, but also for patients with other leukemias and congenital blood disorders. The safety and efficacy of the therapy in people with acute myeloid leukemia will soon be tested in a phase I study. ATLyphe’s work is based on research findings from UZH and ETH Zurich. The company is headed by Markus Manz, professor of hematology and director of the Department of Medical Oncology and Hematology at the University Hospital Zurich, and Dario Neri, professor at ETH Zurich.

The spin-off FimmCyte is researching a new treatment for endometriosis, a disease in which endometrium-like cells grow outside the uterus. Endometriosis often causes severe and chronic pain, affecting an estimated 10 percent of women of childbearing age worldwide. Instead of the usual hormone treatments or operations, FimmCyte is developing an antibody therapy. The antibodies developed by the company are able to recognize a specific protein that is present to excess in endometriosis cells, thus making it possible to treat the affected tissue directly.

The scientific discovery comes from the laboratory of Brigitte Leeners, UZH professor of gynecological endocrinology and reproductive medicine. Two junior researchers in Leeners’ team, Valentina Vongrad and Mohaned Shilaih, discovered this specific protein over-expression and developed the antibody therapy as a result. The treatment is currently in the test phase.

Seito Biologics AG is developing a new immunotherapy for autoimmune diseases such as type-1 diabetes, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Unlike conventional treatments, which suppress the immune system and thus increase the risk of infection and cancer, the spin-off is focussed on therapies that regulate the immune system. The researchers are working with Treg cell engagers with the aim of improving the efficacy of regulators T cells, or “Treg” cells. Treg cells help to keep the immune system in check by preventing excessive or misdirected immune reactions. The innovative therapy improves both the function and the number of these Treg cells, thereby stablizing the immune system and preventing it from mistakenly turning against its own body, as happens in autoimmune diseases. The promising treatment approach is based on research conducted at the UZH chair of clinical immunology and allergology.

Although geospatial data from satellites has been collected for half a century, transforming it into usable information remains a challenge. Currently, such data are mainly analyzed by experts. The spin-off askEarthis dedicated to preparing the comprehensive data in such a way that non-experts are also able to use them to aid decision-making in areas such as environmental management, town planning and resource management. To this end, the company has developed a user interface that makes complex geodata accessible in real time. AskEarth co-founder Simon Grüning is an alumnus of UZH and received support from the Entrepreneur Fellowship Program (see box). The fellowship enabled him to develop his spin-off idea to market readiness.

Although spinal surgery is effective in many cases, there is room for improvement to reduce the rate of complications and increase clinical success. One key project of the spin-off MovingSpine AG is the optimization of the vertebropexy, a process that stabilizes spinal segments by weaving in ligaments and textiles without causing the spine to stiffen. This innovative approach is based on the research work done at the University Center for Spinal Surgery Zurich at Balgrist University Hospital.

Surgical navigation systems are used to perform critical steps in operations with precision. However, the systems also have disadvantages, such as a complicated surgical procedure, an extended operating time and dependence on invasive imaging. Surgical navigation has therefore not yet become standard practice in surgical interventions. The spin-off X23D AG addresses this challenge by developing systems for computer-assisted surgical navigation that can be seamlessly integrated into procedures. The company has designed innovative AI algorithms that collect data directly during a spinal surgery procedure and can display the necessary information in real time. Surgeons thus gain a precise 3D view of the spine, enabling them to carry out the surgery with high precision. The development of this surgical navigation system is based on the research of Philipp Fürnstahl, UZH professor of orthopedic computer sciences at Balgrist University Hospital, and his colleague Hooman Esfandiari.